Heat Shock Protein Expression and Immunity in Chlamydial Infections
نویسندگان
چکیده
منابع مشابه
Heat shock protein expression and immunity in chlamydial infections.
KEY WORDS heat shock proteins, Chlamydia trachomatis, immunity eat shock proteins (hsps) are among the most abundant proteins in nature and are highly conserved amongst both eucaryotes and procary-otes. The heat shock response is an important survival mechanism that safeguards the cell or microbe from conditions of stress. The response is triggered transcriptionally and results in the productio...
متن کاملHeat shock protein and innate immunity.
In addition to serving as molecular chaperones, heat shock proteins (HSPs) have been implicated in autoimmune diseases, antigen presentation and tumor immunity. Extensive work in the last 10 years has also suggested that HSPs such as Hsp60, Hsp70, Hsp90 and gp96, may be potent activators of the innate immune system capable of inducing the production of pro-inflammatory cytokines by the monocyte...
متن کاملEvolution of heat shock protein and immunity.
Heat shock proteins (hsps) are among the most abundant intracellular proteins. Their synthesis is rapidly up-regulated by various 'stressors' including temperature, glucose deprivation, infection and cancer. Certain hsps are able to: (i). associate and chaperone a large variety of cellular peptides; (ii). be efficiently internalized by antigen presenting cells (APC) through receptor-mediated en...
متن کاملHigh Sensitivity C–Reactive Protein and Im-munoglobulin G against Chlamydia Pneumo-niae and Chlamydial Heat Shock Protein-60 in Ischemic Heart Disease
Background: Inflammation and infectious agents such as Chlamydia pneumoniae have been associated with cardiovascular disease. Objective: To evaluate the serum high sensitivity C - reactive protein (hs-CRP) and antibodies against Chlamydia pneumoniae and Chlamydial heat shock protein-60 (Cp-HSP60) in patients with ischemic heart disease (IHD). Methods: 62 patients with IHD having either acute my...
متن کاملChlamydial heat shock proteins and trachoma.
Two chlamydial proteins (HSP-60 and HSP-70) have marked homology with bacterial and mammalian heat shock proteins. Previous studies have indicated that when inoculated into the eyes of immune animals, a Triton X-100 extract of chlamydia containing HSP-60 induces an ocular delayed-type hypersensitivity reaction. The potential for HSP-70 to induce a similar reaction was tested in six cynomolgus m...
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ژورنال
عنوان ژورنال: Infectious Diseases in Obstetrics and Gynecology
سال: 1999
ISSN: 1064-7449,1098-0997
DOI: 10.1155/s1064744999000149